2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-124346
    T-3364366 1356354-09-0 ≥99.0%
    T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay.
    T-3364366
  • HY-128741
    D-Allose 2595-97-3 99.85%
    D-Allose is an endogenous metabolite.
    D-Allose
  • HY-128742
    Thiamine monophosphate (chloride) dihydrate 273724-21-3 99.31%
    Thiamine monophosphate chloride dehydrate is a source of Vitamin B1 (HY-A0100). Thiamine monophosphate chloride involves being absorbed and converted to thiamine in the body. Thiamine monophosphate chloride is mainly used in the research of food supplements as a vitaminB1 source to meet the nutritional needs of the body.
    Thiamine monophosphate (chloride) dihydrate
  • HY-136497
    Coenzyme FO 37333-48-5 99.06%
    Coenzyme FO, a deazaflavin chromophore, acts as an important hydride acceptor/donor in the central methanogenic pathway.
    Coenzyme FO
  • HY-138802
    ML089 1306638-12-9 99.86%
    ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC50 of 1.3 µM. ML089 can be used for the research of congenital disorder of glycosylation Ia.
    ML089
  • HY-141525
    SCD1 inhibitor-4 1295541-87-5 98.93%
    SCD1 inhibitor-4 is a potent, orally active stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.
    SCD1 inhibitor-4
  • HY-141578
    C18:1-Ceramide 5966-28-9 99.93%
    C18:1-Ceramide is a ceramide subspecies. C18:1-Ceramide can be used in the study of type 2 diabetes
    C18:1-Ceramide
  • HY-141699
    FATP1-IN-1 1431945-95-7 99.55%
    FATP1-IN-1 (compound 5k) is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC50 values of 0.046 μM or 0.60 μM, respectively.
    FATP1-IN-1
  • HY-143227
    DK3 1187568-16-6 99.82%
    DK3 is a potent and selective estrogen-related receptor alpha (ERRα) agonist.
    DK3
  • HY-14658A
    (S)-Thalidomide 841-67-8 99.52%
    (S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) .
    (S)-Thalidomide
  • HY-147372
    SJ000063181 945189-68-4 98.92%
    SJ000063181 is a potent BMP signaling activator with an EC50 ≤1 µM. SJ000063181 can be used as chemical probes to interrogate BMP signaling due to it can penetrate zebrafish embryos.
    SJ000063181
  • HY-B1745A
    Pyridoxylamine dihydrochloride 524-36-7 99.93%
    Pyridoxylamine dihydrochloride is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.
    Pyridoxylamine dihydrochloride
  • HY-P1215A
    HS024 TFA 99.80%
    HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake.
    HS024 TFA
  • HY-P1504A
    β-Melanocyte Stimulating Hormone (MSH), human TFA 99.51%
    β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.
    β-Melanocyte Stimulating Hormone (MSH), human TFA
  • HY-P1663A
    ATWLPPR Peptide TFA 99.81%
    ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis. ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes.
    ATWLPPR Peptide TFA
  • HY-P99614
    Fazpilodemab 2517935-02-1 ≥99.0%
    Fazpilodemab (BFKB8488A) is a humanized, agonistic, bispecific antibody targeting fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD).
    Fazpilodemab
  • HY-101400A
    Deoxycytidine triphosphate (trisodium) solution (100mM) 109909-44-6 ≥99.0%
    Deoxycytidine triphosphate trisodium (dCTP trisodium) solution (100mM) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium salt has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
    Deoxycytidine triphosphate (trisodium) solution (100mM)
  • HY-N0324S2
    Cholic acid-13C 52886-36-9 ≥98.0%
    Cholic acid-13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
    Cholic acid-13C
  • HY-N0390S5
    L-Glutamine-1-13C 159663-16-8 ≥98.0%
    L-Glutamine-1-13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.
    L-Glutamine-1-13C
  • HY-N0486S8
    L-Leucine-13C6,15N 202406-52-8 ≥99.0%
    L-Leucine-13C6,15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-13C6,15N
Cat. No. Product Name / Synonyms Application Reactivity